STUDY OF OXIDATIVE STRESS PARAMETERS OF TEMPORAL CORTEX AND OPEN-FIELD ACTIVITY IN RAT EXPOSED TO ALUMINIUM AND ETHANOL IN PRESENCE OF α-TOCOPHEROL SUPPLEMENTATION

Abstract

In several attempts, supplementations with α-tocopherol have been successfully utilized to restrict or reduce the neurotoxic effects of aluminium, particularly the oxidative stress caused by aluminium. As it is already known that pro-oxidant dominance augment the neurotoxic effects of aluminium, the current study has been carried out to find whether exogenous antioxidant supplementation can lessen the aluminium-induced neurotoxicity even in prooxidant dominant condition. Male Wistar rats were treated with either aluminium or ethanol or both for 4 weeks along with oral α-tocopherol supplementation. All the oxidative stress parameters of temporal cortex were evaluated and found to remain undisturbed after 4 weeks of simultaneous exposure to aluminium and ethanol, except level of lipid peroxidation. Statistical evaluation of open-field activity also demonstrated no significant intra-group variation in ambulatory parameters as well explorative parameters. However, trend-line analysis against time scale demonstrated appreciable differences in some of the open-field parameters. From this study, it can be suggested that the current dose of α-tocopherol supplementation has provided some degree protection against pro-oxidant exacerbated of aluminium-induced neurotoxicity. However, studies with higher level of α-tocopherol supplementation may provide evidence of usefulness of it against neurodegeneration.