PROBLEMS OF ANDROPAUSE AND POSSIBLE REMEDIES

Abstract

Andropause or PADAM (partial androgen deficiency in aging males) or ADAM (androgen deficiency in aging males) or AAAD (aging associated androgen deficiency) or late onset hypogonadism is a clinical condition characterized by a partial deficiency of bio-available androgens and/or its decreased sensitivity in target tissues affecting reproductive activity that has a similarity with female menopause. This state of hypogonadism leads to a decline in physical energy and altered state of well-being, irritability, occasional sweating, sexual
dysfunction and various metabolic alterations. These changes may have deleterious effects on muscle mass, bone density, cardiovascular efficiency, lipid profile and eventually cognitive functions. The diagnosis of andropause depends mainly on clinical features and laboratory investigations. As the onset is gradual and many of the symptoms are common with elderly persons, diagnosis is difficult. The common treatment is testosterone supplementation, which has positive effects on improving the symptoms and quality of life. This therapy has some reported side effects that are also to be considered during long-term use. Awareness about the condition may help to diagnose it earlier and multi-dimensional long-term studies are required to elucidate the mechanism of the symptoms and its possible prevention through Testosterone Replacement Therapy (TRT).