Osteoporosis: A Silent Life Threatening Disease
Osteoporosis: A Silent Life Threatening Disease
DOI:
https://doi.org/10.55184/ijpas.v73i1.23Keywords:
Osteoporosis, BMD, Risk factors, Post-menopausal womenAbstract
Osteoporosis is a pervasive multi-factorial chronic disorder, characterized by low bone mineral density and increased risk for bone fragility, with a claim for long term management procedure. Osteoporosis as a disease in general is a major threat due to our changed life style and aging demographic. It may be viewed as a heterogeneous condition which may occur due to various genetic, nutritional, mechanical, endocrine and other life style factors. Although post- menopausal women are the most vulnerable victims, aged men population cannot escape themselves from this disease, as can be diagnosed by Bone Mineral Density (BMD) test. This review work will give an insight about how the disease can be controlled by change in life style along with usage of some selected pharmaceuticals and nutritional supplements. Hence assessment of the prevalence and awareness of the risk factors associated with the disease may provide the basis of management and future health plans to combat it.
References
Abd- Alhameed Intissar, Saba Elias, Darwish H M.(2010). Prevalence and awareness of osteoporosis among postmenopausal Palestinian women. Arch Osteoporos ,(5):111–118.
Bilezikian, J.P.(1999) Osteoporosis in Men ,The Journal of Clinical Endocrinology and Metabolism: 84 (10) :3431-3434.
Dharmalingam, M. Prasanna Kumar, KM. Patil, J .Karthikshankar, S.(2003) Study of Bone Mineral Density in Post menopausal women. Bone: 32 (Suppl): S 178.
Ginaldi, Lia. Di Benedetto, De Martinis. Massim. (2005) Osteoporosis, Inflammation and ageing Immunity and Aging 2:14-24.
Jeyalakshmi, S. Chakrabarti, S. Gupta, N. (2011): Situation Analysis of the Elderly in India , Central Statistics Office, Ministry of Statistics & Programme Implementation , Government Of India.New Delhi, India.
Keramat, A. Mithal, A. (2005) Risk factors for osteoporosis in urban Asian Indian women presenting for a preventive health check up 2nd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, Geneva June 25-29.
Lo, C W. Paris, PW., Holick, MF.(1986) Indian and Pakistani immigrants have the same capacity as Caucasians to produce vitamin D in response to ultra violet irradiation‖. Am J Clin Nutr: 44: 683-5.
Looker, AC. Orwoll, JS. Johnston, CC. Jr (1997) . Prevalence of low femoral bone density in older U.S women from NHNANES III.‖ J Bone Miner Res :12:1761.
Mitra, S. Desai,.M. Ikram, M. (2006) Vitamin D receptor gene polymorphism and bone mineral density in postmenopausal Indian women Maturitas 10:55 27-35
Malhotra, N. and Mithal, A. (2008) Osteoporosis in Indians. IJMR: 127: 263-268.
Pothiwala, P. Ellen. M Evans. (2006) ―Ethnic variation in risk for osteoporosis among women: A review of Biological and Behavioural Factors. Journal of Women‘s Health. 15 (6). 709-19.
Nguyen VH (2017) Osteoporosis prevention and osteoporosis exercise in community-based public health programs. Osteoporosis and Sarcopenia 3:18-31
Randell, A., Sambrook, PN. Nguyen, TV. Eisman JA (1995) Direct clinical and welfare costs of osteoporotic fractures in elderly men and women . Osteoporos Int. 5(6):427-432.
Richy, F. Schacht, E. Bruyere, O. Ethgen, O. Gourlay,M. Reginster, Y-J.(2005) ―Vitamin D analogs versus native vitamin D in preventing bone loss and osteoporosis related fractures. A comparative meta analysis. Calcify Tissue Int. 76(3): 176-186
Rosen, CJ. Dimai, HP. Vereault, D.( 1997) Circulating and skeletal insulin like growth factor -1 concentrations in two inbred strains of mice with different bone mineral densities. Bone 21: 217-223.
Shin, A. Lim, S. Sung, J. Myung, S. Kim, J. (2010) Dietary habit and bone mineral density in Korean post menopausal; women. Osteoporos Int 21(6):947-955.
. Tandon, N. Maraha, RK. Kalra, S. Gupta, N. Dudha, A., Kochupillai N.(2003) .Bone mineral parameters in healthy young Indian adults with optimal Vitamin D availability‖ Natl Med J India 16:298-302.
The WHO study group (1994). Assessment of fracture risk and its application to screening for post menopausal osteoporosis. Geneva. World health Organization .1994
Vaananen, HK. H Zhao, Mulari, M. Halleen, JM. (2000). The cell biology of osteoclast function‖ . J cell science 113:377-81.
Iwamoto J (2017) A role of exercise and sports in the prevention of osteoporosis. Clin Calcium .27(1):17-23.
Mirza F, Canalis E (2015). Secondary Osteoporosis : pathophysiology and management. European society of Endocrinology. 173(3) R131-R151.
Holzer LA, Leithner A and Holzer G (2015) The Most Cited J Osteoppros Papers in Osteoporosis and Related Research. Published online 2015 Jan 31. doi: 10.1155/2015/638934
Khadilkar A V and Mandlik RM (2015) Epidemiology and treatment of osteoporosis in women: an Indian perspective. Ini J Womens Health 7: 841–850
Howard A (2011) Coding for bone diseases, For The Record, 23(9): 27
Rutherford O (1990). The role of exercise in prevention of osteoporosis. Physiotherapy, 76 :522–526.
L. A. Milliken, J. Wilhelmy, C. J. Martin, Lohman T J (2006) Depressive symptoms and changes in body weight exert independent and site-specific effects on bone in postmenopausal women exercising for 1 year. Journals of Gerontology A: Biological Sciences and Medical Sciences, 61(5). 488–494,
K. Chan, L. Qin, M. Lau et al. (2004) A randomized, prospective study of the effects of Tai Chi Chun exercise on bone mineral density in postmenopausal women,” Archives of Physical Medicine and Rehabilitation. 85(5):717–722.
A. G. Robling, A. B. Castillo, and C. H. Turner (2006) Biomechanical and molecular regulation of bone remodeling, Annual Review of Biomedical Engineering, 8: 455–498.
P. Collet, D. Uebelhart, L. Vico (1997) Effects of 1and 6-month spaceflight on bone mass and biochemistry in two humans. Bone. 20(6): 547–551.
Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R (2014). Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 25:2359–81.
Vaishya R, Vijay V, Agarwal Ak, Maheswari P (2017) Assessment of osteoporotic fracture risk in urban Indian population using quantitative ultrasonography & FRAX tool. Indian J Med Res. 146(Supplement)S51-S56.
Sozen Tummy, Ozisik L, and Nusel Calik Basaran. (2017). An Overview and management of Osteoporosis. Eur.J.Rheumatol. 4(1): 46–56)
Khadilkar AV and Mandlik RM (2015) Epidemiology and treatment of osteoporosis in women: an Indian perspective. Int J Womens Health . 7: 841–850.
Seeman E, Delmas PD.(2006). Bone quality--the material and structural basis of bone strength and fragility. N Engl J Med. 354:2250–6.
Cooper C, Melton LJ.( 1992) 3rd Epidemiology of osteoporosis. Trends Endocrinol Metab. 3:224–9.
Melton LJ, 3rd, Achenbach SJ, Atkinson EJ, Therneau TM, Amin S.(2013). Long-term mortality following fractures at different skeletal sites: a population-based cohort study. Osteoporos Int.;24:1689–96.
Siminoski K, Warshawski RS, Jen H, Lee K..(2006) The accuracy of historical height loss for the detection of vertebral fractures in postmenopausal women. Osteoporos Int.: 17:290–6.
Ensrud KE, Ewing SK, Taylor BC, Fink HA, Stone KL, Cauley JA, Cawthon PM. (2007). Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci.: 62(7) :744– 51
Compston J, Bowring C, Cooper A, Cooper C, Davies C, Francis R, et al (2013). Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013. Maturitas.;75:392–6.
Ross AC, Taylor CL, Yaktine AL, Del Valle H B (2011)., editors. Institute of Medicine (US) Committee to Review. Dietary Reference Intakes for Vitamin D and Calcium. Washington (DC): National Academies Press (US)
Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A.(2008). Case finding for the management of osteoporosis with FRAX--assessment and intervention thresholds for the UK. Osteoporos Int.19:1395
Vasikaran S, Eastell R, Bruyere O, Foldes AJ, Garnero P, Griesmacher A (2011). Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 22:391–420.
Mithal A and Kaur P.(2012) Osteoporosis in Asia: A call to action. Curr Osteoporos Rep;10:245-7
Sridhar CB, Ahuja MM, Bhargava S (1970). Is osteoporosis a nutritional disease? J Assoc Physicians India 18:671-676.
Khanna P, Bhargava S.(1971). Roentgen assessment of bone density in North Indian population. Indian.J.Med.Res; 59:1599-609.
Smit R(1993). Bone physiology and the osteoporotic process, Resp Med :87 Suppl A :3-7.
Compston J, Cooper A, Cooper C et al (2017). UK Clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos .12(1) :43 [Published online 2017 Apr 19. doi: 10.1007/s11657-017-0324-5]
