Indian Journal of Physiology and Allied Sciences

Tregs suppress macrophage tumoricidal functions

Authors : POULAMI SAHA,
POULAMI SAHA

Department of Zoology, Balurghat College, Balurghat, West Bengal.

TATHAGATA CHAKRABORTY,
TATHAGATA CHAKRABORTY
(Corresponding Author)

Department of Zoology, Balurghat College, Balurghat, West Bengal.

Address

Department of Zoology, Balurghat College, Balurghat, West Bengal.

Address

Department of Zoology, Balurghat College, Balurghat, West Bengal.

Page : 21-27 , vol : 69 ,No : 1 , Year : 2015

Abstract

Macrophages are well-known for their tumoricidal functions. In order to ascertain the effect of Regulatory T cells (Tregs) on macrophage tumoricidal functions, macrophages purified from healthy individuals were co-cultured with Tregs for 48 hours and cytotoxicity assay was performed with macrophage sensitive lymphoma cells, U937. Results clearly suggested that Tregs significantly inhibit (p<) macrophage mediated tumor cell killing, as observed in cultures using different E:T ratios.

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Research Article
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